Chemical Exposure

3 important questions on Chemical Exposure

How does bisphenol A (BPA) affect the epigenome?

Mouse agouti model: shift coat color to yellow: DNA demethylation. Increased risk of developing obesity.
Supplementation with methyl-donating substances, ie choline/folic acid/vit B12, counters BPA effects.
Genistein (soy product) inhibits Dnmt activity-> DNA methylation

How does vinclozulin affect the epigenome?

funigicide, androgen receptor antagonist. Decreases sperm quality up to F4 generation. Changes methylation patterns in sperm cell DNA. Also alters physiology, behavior, metabolic activity and transcriptome in brain nuclei in F3 generation.

How do HDAC inhibiotrs (HDACi) affect the epigenome, causing fetal valproate syndrome?

Affects retinoic acid (RA)-induced regulation of Hox-genes, which determine the basic structure and orientation of an organism. Affects anterior-posterior patterning. 
Fetal valproate syndrome: subtle facial characteristics.

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