Bioassays - Promises and pitfalls of bioassays in food safety - Promises

6 important questions on Bioassays - Promises and pitfalls of bioassays in food safety - Promises

What is the promise in detection of unknown congeners in a bioassay?

Detection is based on biological activity and not on pre-defined compounds that can be detected. So you don't neet to know what the compound is in order to screen for it.
After the bioassay is positive you can identify the compound with chemical methods.

What is the promise in the bioassays guided fractionation?

With bioassays you can fractionate mixtures and facilitate isolation of the biologically active ingredient(s).

You can screen for bad compounds in your ingredients and you can see if it is in your polair or unpolair groups enz. This is done by testing the different clean ups of your sample.

What is the promise in the bioassays overall potency of mixtures?

You can see how dangerous your food or environment really is.

  • environmental samples: (surface and soil water, waste water treatment plants, water sediments, air, soil. organisms)
  • food samples: dairy products, eggs, food supplements, fish, meat etc  
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What is the promise of high throughput in bioassays?

Bioassays allow rapid screening of high number of samples
Only suspected ones to be analysed by expensive analytical techniques
Usefull in case of a food incident; bioassays used as a first rapid prescreen

What is the promise of bioassays as an alternative for animal testing in endpoint testing?

Bioassays are made to replace animal tests. For this they use the mechanism of the animal but they don't need the animal anymore to detect it.  

These alternative methods always have to just as potent as the animal tests.

What is the promise of bioassays in termes of high sensitivity?

There sensitivity is comparable to chemical analysis.

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