Central fatigue: Issues related to cognition, mood and behavior, and psychiatric diagnoses

6 important questions on Central fatigue: Issues related to cognition, mood and behavior, and psychiatric diagnoses

Give a definition of central fatigue

Central fatigue defined as failure to initiate and or sustain attentional tasks and physical activities requiring self motivation

Name two incorrect assumptions often made about central fatigue

1.   subjective and objective reports of fatigue correlate

2.  cognitive fatigue always results in performance decrement

Name two problems with self-reports of fatigue

1. Focusing on small subset of sources of fatigue perception

2. construct contamination known to be independent of fatigue are included in questionnaires
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What areas in brain are thought to correlate with central fatigue?

1. Basal ganglia

2. OFC

3. Superior parietal lobule  

Regions to increase in brain activity when fatigue plays a role but when there is no performance decrement

What is the underpinning of disentangling psychiatric and neurological fatigue?

Increase tryptophan causes increase in serotonin (involved in sleep regulation). Excessiveness of both leads to tiredness or fatigue, the increases serotonin may increase mental effort required for tasks

How is tryptophan correlated with depression and fatigue?

Low levels: depression
High levels: fatigue

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