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Antiepileptic drugs and suicidality: An expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology

3 important questions on Antiepileptic drugs and suicidality: An expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology

An alert was send to health care professionals about an increased risk of suicide ideation and behavior in people treated with antiepileptic drugs. The meta-analysis was done by the FDA. Name 4 methodological flaws of this study

1.  assessment suicidality was based on spontaneous reports (not in systematic prospective manner or randomized.

2.  FDA warning risk for all antiepileptic drugs (AED) where only two significantly caused more suicidal thoughts (of 11)

3.  Studies also included patients taking adjunctive therapy, unclear what caused the suicidality

4. Suicidal behavior was greater in certain geographic regions
 

The relationship of suicide and epilepsy is called complicated. Why?

1. Epilepsy complicated by psychiatric comorbidities. 90% commiting suicide has psychiatric disorder.

2.  Bidirectional relationship epilepsy and suicide: common pathogenic mechanisms

What is evidence for suicide with AED in patients with epilepsy

Rapid titration of the drug in patients with mesial temporal lobe epilepsy and history of depression have been identified as major determinants for suicide in majority of cases

The question on the page originate from the summary of the following study material:

Advanced CN suicidality week 4

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