Probiotics

18 important questions on Probiotics

What is the oral micro flora?

The environment is rich in oxygen.

Many different. On the surface airobe, between the tooth anairobe.

What is the defence mechanism of the body against bacteria?

Acid from stomach and bile

What is the micro flora that can grow in the small intestins, and how many is there?

You start with 10^3 microorganisms
First the aerobic micro-organisms like ecoli start to grow. Later the anaerobic micro-organisms
You end with 10^9 microorganisms
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How are the conditions in the LI and how manic MO are there?

It is worm (37 degrees), neutral pH.
10^9 go in and 10^11 come out. This is 1 to 10% of the feces.

What is the intenstial micro flora?

Depends on where in the body you are. Everywhere it is different.
So with fecal analysis you only analyse the population at the end.

What to groups of M.organisms are there in the intestinal microflora?

  • The dominant or resident bacterial flora. (Always there)
  • The transient bacterial flora (moste often small intestinal or oral bactiera) different from  person to person

On what does the micro flora depend?

Depending on:
- Host
      - Species
      - Individual
- Genetic factors
- Diet

What doe the bacteria in or stomach do?

  1. Absorption/digestion: fermentation/microbial enzymes
  2. Protection: inhibition of pathogens
  3. Bile: modification of bile salts
  4. Stimulation
  5. Anti-mutagenic activity
  6. Formation of mutagens

What determonts how well things are fermented?

Time! For how long things are in the intestines.

How does the primary metabolism in the large intestine go?

Zie afbeelding

How can you influance the intestinal microflora?

  1. By competition and exclusion (probiotics, antibiotics)
  2. By changing the metabolism: Prebiotics 

How does the approach competition and exclusion work?

You need to restore the bacterial disbalance because:
  • Small intestinal overgrowth
  • Antibiotic-associated diarrhea prevention
  • Foodborne (oral) pathogens, can make you sick because there is no protection.

This approach can only work in the small intestens.

Why does probiotics have no effect in the small intestines?

This is because there is less compition with micro-organism. This is because you need twice as much micro-organism as is present in the intestents in order to have an effect.

How does a product influencing the metabolism work?

By Changing the metabolic patterns:
  • reducing/stimulating enzymes
  • reducing/pH
  • increasing fermentation

Changing bacterial composition
  • Selective stimulation of certain groups


This is doen by adding certain substrates: prebiotics

The main target is the large intestine. Not much bacterial metabolism in the small intestine.

Why is naming all bacteria not that important?

It is more important to know what all the bacteria together do. So you can influance this instead of giving a name to everything.

What is the official definition of probiotics?

Oral probiotics are living micro-organisms which, upon digestion in certain numbers, exert health benefits beyond inherent basic nutrition’.

Why do probiotic products do not exist?

This is because a product contains probeotics. It is not made of probiotics.

On what is the effect of a probiotic dependent?

It is STRAIN dependent.

The question on the page originate from the summary of the following study material:

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