The three R's of DNA metabolism - Telomeres
7 important questions on The three R's of DNA metabolism - Telomeres
Linear chromosomes cannot be replicated entirely using discontinuous DNA synthesis, why?
The lagging strand will therefore bear a single strand 3'-overhang that moves further into the chromosome with each replication
What are 6 characteristics of telomerase?
2. RNA dependent DNA polymerase
3. Replicates and elongated telomeres of chromosomes
4. Enzyme that carries internal RNA template
5. Only active in stem cells
6. Too high levels --> tumor formation --> cancer
What happens if the T-loop or telomeric repeats are not maintained?
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What happens if telomerase is absent (after 40-60 cell cycles)?
How do dicentric chromosomes inhibit cell division?
When do breakage fusion cycles occur?
What are the antagonistic effects of telomerase on longevity?
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