LE 4: Transcriptoinal control of gene expression III - Heat shock response
3 important questions on LE 4: Transcriptoinal control of gene expression III - Heat shock response
What kind of process is the heat shock response?
Regulatory feedback loop
How does the heat shock response work? (5 steps)
1. Heat shock proteins engage in chaperoning other proteins
2. HSF1 is released and trimerizes
3. HSF1 is transported into the nucleus
4. HSF1 is hyperphosphorylated
5. HSF1 bind the promoter of heat shock genes
2. HSF1 is released and trimerizes
3. HSF1 is transported into the nucleus
4. HSF1 is hyperphosphorylated
5. HSF1 bind the promoter of heat shock genes
Where is pausing of Pol II found?
In developmentally regulated genes and house-keeping genes
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