Cancer - miRNAs in cancer

3 important questions on Cancer - miRNAs in cancer

Which two miRNAs are causatively linked to cancer?

MiR15a and miR-16-1

What is the effect of miR15a/miR-16-1 cluster transfection in leukemia?

Significant reduction of BCL2 protein levels

When do the tumor suppressor functions of miRNAs manifest?

When their levels are reduced below critical levels, either by a reduction in a gene dosage or some other mechanism

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