LE 3: Transcriptional control of gene expression II - Transcription initiation
3 important questions on LE 3: Transcriptional control of gene expression II - Transcription initiation
Which components can influence the efficiency of PIC formation?
Activators and repressors
What is the process of PIC foramtion in vitro? (6 steps)
1. TFIID binds to the core promoter and bends the DNA
2. TFIIB binds downstream of TBP and stabilizes its binding
3. Pol II and TFIIF are recruited
4. TFIIE binds
5. TFIIE enabled binding of TFIIH
6. TFIIH uses ATP to pry apart the double helix at the transcription start point, allowing transcription to begin
2. TFIIB binds downstream of TBP and stabilizes its binding
3. Pol II and TFIIF are recruited
4. TFIIE binds
5. TFIIE enabled binding of TFIIH
6. TFIIH uses ATP to pry apart the double helix at the transcription start point, allowing transcription to begin
What is the difference between PIC formation in vivo and in vitro?
In vivo the holo-enzyme complex is formed beforehand
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