Cancer - Sustaining proliferative signaling

4 important questions on Cancer - Sustaining proliferative signaling

How does proliverative signaling in normal cells work?

Controlled production and release of growth promoting signals for entry and progression into cell cylce

What are the 4 (possible) changes in proliverative signaling in cancer cells?

1. Selfproduction of growth factor ligands and receptors (self stimulation)
2. Stimulate normal cells to produce necessary growth factors
3. Elevating levels of receptor proteins
4. Constitutive activation of downstream components

What is the effect of oncogenic transfortmation?

Cells continue growing, they don't become quiescent
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What is the effect of the RasD oncogene?

Bound GTP is hydrolized very slowly, constanly active

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