LE 3: Transcriptional control of gene expression II

6 important questions on LE 3: Transcriptional control of gene expression II

Can eukaryotic cells have more than one core promoter?

Yes

What is the function of the mediator complex?

It mediated the bridge between RNA Pol II and activators/repressors

What are the differences between the transcription initiation of Pol II and Pol I/III?

Different control elements, different general transcription factors, Pol I and III don't require ATP
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What is the function of an enhancer?

Increases transcription form a distance and can interact with cell type specific activator proteins

What is the effect of combining transcription factors?

It increases the complexity of regulation, increases the number of binding possibilities

What is special about activator domains of nuclear receptors?

More structured, undergoes conformational changes upon ligand binding

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