Cell cycle I - Spindle checkpoint
3 important questions on Cell cycle I - Spindle checkpoint
By which two substrate specificity modulators regulate the activity of the E3 ubiquitin ligase APC?
1. Cdc20: APC adaptor for the anaphase inhibitor Pds1
2. Cdh1: APC adaptor that is part of mitotic exit network
2. Cdh1: APC adaptor that is part of mitotic exit network
How is the metaphase/anaphase transition controlled?
The spindle checkpoint: cohesin rings keep sister chromatids together, the rings must be dismantled to segregate the sisters,
How can the metaphase/anaphase transition be delayed at the checkpoint?
As long as there is even only one unattached centromere the metaphase/anaphase transition is delayed
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