THE GENETICS OF ALZHEIMER’S DISEASE
3 important questions on THE GENETICS OF ALZHEIMER’S DISEASE
What makes the evidence from autosomal forms of Alzheimer important with regard to the sporadic forms of Alzheimer?
They have very similiar pathology (neurofibrillary tangles and microglia infiltration)
Several forms of Alzheimer are autosomal dominant, where do their pathologies converge?
All of them result in a higher ratio of secreted amyloid beta 42, which is more toxic than its counterpart amyloid beta 40.
What is the most important relation between apo E and Alzheimer's Disease?
apo E is very good at binding amyloid beta, increasing clustering.
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