Cellulair communication - Adhesion molecules

4 important questions on Cellulair communication - Adhesion molecules

What is the main function of adhesion molecules?

Facilitating processes where close contact of cells is required (directing cell migration, phagocytosis and cellular cytotoxicity)

To what can signal transduction after ligation of the adhesion molecule lead?

- Cell activation

- Alteration receptor expression

- Cytokine production

- Effects on cell survival

How can adhesion molecules be expressed?

- Cells can express them constitutively

- Proinflammatory molecules (complement activation products, microbial metabolites)

- Some mainly on leucocytes

- Some on endothelial cells

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Adhesion molecules families are based on structure and function. What are the main ones?

- Intercellular adhesion molecules

- Intergrins

- Selectins

- Cadherins (calcium dependent adherins)

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