Discrimination of pathogens by the innate system
3 important questions on Discrimination of pathogens by the innate system
On what ground does the innate system discriminates?
They discriminate foreign molecules from self.
In what three groups does the pattern-recognition receptor molecules fall depending on function?
1. Those inducing endocytosis (enhancing antigen-presentation)
2. Those initiating nuclear factor κβ transduction and cell activation (toll like receptors)
3. Those which are secreted acting as opsonins (mannan binding lectin for example)
What is the importance of the knowledge of recognition pathways?
It highlights the close relation between the innate and specific respons; a pattern-recognition receptor recognises broad patterns on microbes and then presents the processed product to antigen-specific T-cell
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