Mucosal immune maturation in chicken

4 important questions on Mucosal immune maturation in chicken

Early life conditions that influence immune competence in later life:

  • Bacteria on eggshell
  • Contact hen
  • Hygiene
  • Feed
  • Environmental conditions

Factors that influence immune maturation

  • Maternal Immunity
  • Diet
  • Commensal bacteria
  • Pathogens
  • Vaccination
  • Stress
  • Genetic background

Mucosal dendritic cells:

  • Sample and process antigens
  • Expose antigens to other cells
  • Provide signals to direct the immune respons
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Four ways of antigen uptake by dendritic cells:

  1. M cell-dependent
  2. DC-dependent
  3. FcRn dependent
  4. Apoptosis dependent

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