Summary: Antenatal Care

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  • 1 Antenatal Care

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  • Down's Syndrome Screen

    Combined Test from weeks 11-14
    ß-hCG
    PAPPA 

    Quad test from weeks 15-22
    AFP
    ß-hCG
    Inhibin
    E3 

    Nucheal translucency and age
  • Medications for 1st Trimester

    Folic acid 0.4mg/day until week 12
    Vitamin D 10µg/day if BMI>30 or low sun exposure
  • NICE Guidelines of Number of Appointments

    10 for nulliparous
    7 for multiparous
    More frequent in high risk

    Blood pressure taken
    Urine checked for protein; glucose; leucocytes and nitrates
  • Immune Foetal Hydrops

    Rhesus isoimmunization
    IgG crosses placenta causing death of foetal red blood cells
    Anaemia and then hydrops can occur

    Initial pregnancy IgM is formed which cannot cross placenta
    Re-exposure = IgG and causes haemolytic anaemia
  • Sensitising events for Rhesus disease (6)

    TOP or ERPC
    Ectopic
    Vaginal bleeding > 12 weeks
    Blunt abdominal trauma
    Amniocentesis/CVS
    Intrauterine death
    Delivery
  • Management of Rhesus Disease

    Checked for antibodies at 28 & 34 weeks
    Test father
    If levels of antibodies are >10lU/ml then assess foetal anaemia

    Can give transfusion in umbilical vein and repeat every 2 weeks
    Give blood transfusion at birth
  • Prevention of Rhesus (D) disease

    Anti-D given at 28 weeks or 72 hours of sensitizing event
    After delivery if neonate has rhesus +ve
  • Non-immune foetal hydrops causes

    Severe anaemia (virus; G6PD; Thalassaemia)
    Cardiac (structural; tachyarrhythmia; heart block)
    Chromosomal (13;18;21;45XO)
    Twin-to-twin transfusion syndrome
    Placental
    Other infections
    Other genetic
    Other structural
  • Investigations of non-immune foetal hydrops

    Ultra-sound gives diagnosis
    Can look for structure problems and anaemia by MCA velocity
  • Treatment of non-immune foetal hydrops

    Correct any causes if possible
    Twin-to-twin = laser photocoagulation
    Cardiac if possible
    Deliver if in 3rd trimester
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