Drugs and Food - Powerpoint II
7 important questions on Drugs and Food - Powerpoint II
What is the U-shaped curve of DA?
- Both low and high DA are associated with low cognitive performance
- We all inherently want to optimise this bij using CNS stimulants or depressants or both.
- Effects depend on:
- Type and diffuculty task
- Genetics predisposition
- Type of drug (stim/depres)
- Dosage, consumption history
- Age, gender, disease, infection, immunity
What is the effect of amphetamine on val vs met on Wisconsin & N-back tasks?
- Measured:
- % preservation error ~ updating
- BOLD signal ~PFC efficiency
What is the effect of a dosage of dopamine on chronic users on the Stop-Signal task?
Cocaine makes inhibition worse, the ability to stop drug use will be worse too because your inhibition is fucked up
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How is Tyrosine effective in reversing DA depletion/stress?
What is serotonin and it's effects?
Associated with:
- Sleep, mood, agression
- OCD (reduced information processing)
- Low - depression, autism, OCD
- High - serotonin syndrome
- Less affiliative behavior (social/emotional bonding)
- Incresed aggression
- Stronger response to seeing unfairness
- Bias to negative stimuli
Tryptophan induces a +ve emotional bias?
1. Amphetamine effects PFC COMT-genotypes differently: - On AMP, Val-individuals show a/an ___________ in performance on ________________ type of tasks - At _______ task load, Met-carriers on AMP perform _________ than Val-carriers. 2. Long-term and Recreational drug users are __________ than non-users in time-critical situations like _________. Lifetime exposure to cocaine is ________ correlated with the extent of this deficit. 3. In ____________ situations, Tyrosine supplements can ___________ DA depletion. 4. Reduced serotonin activity leads to less ____________ and more ____________ behavior. 5. ____________ is a supplement that is useful in reducing __________ and promoting sleep.
High task load, Met on AMP perform worse
LT drug users are worse in time critical situations like driving, Coke is positively correlated
Stressful, reverse
affiliative, agressive
Tryptophan, anxiety
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