Applied parasitology - immune mediated diseases
6 important questions on Applied parasitology - immune mediated diseases
Properties of Atopic diseases:
- Fast hypersensitive response because of genetic tendency to produce IgE
- specific to 'harmless' antigens abundantly present in environment
- often type 2 immunity (asthma, hay fever, food allergies)
What happens with Atopic diseases for first and second time exposure?
- First time exposure -> allergen binds to Th2 -> B cell activated -> IgE produced -> Mast cells/basophils (FcR) are activated = sensitization
- Second time exposure: mast cell/basophil (FcR) sensitized -> degranulation of prostaglandins, histamines, cytokines and chemokines -> acute inflammatory response -> hypersensitivity
What are autoimmune diseases and how are they developed?
Development: unbalanced immune response by reduced susceptibility of Treg (regulatory T cells) by T-effector cells.
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What happens with type 2 immune response against helminths?
What happens in the first line of defence immune modulation?
Helminths have components in their saliva that stop the release of alarmins -> stops type 2 immune response
What happens in the second line of defence immune modulation?
alternatively activated macrophages for enhanced wound healing (also produce anti-inflammatory cytokines) -> eosinophils kill helminths
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