Fungi - Fungal diseases

6 important questions on Fungi - Fungal diseases

Properties of superficial mycoses:

  • Fungi do not cause a host cellular response
  • 'infections' do not cause pathology
  • patients only gets concerned of cosmetic reasons and not of discomfort
  • generally affects stratum corneum (hoornlaag) of skin and hair

Properties of athelete's foot:

Athlete's foot = tinea pedis (second most common skin disease)
several different fungi and transmitted in moist environments (with people with bare feet)

Properties of subcutaneous mycoses:

  • Infections involve deeper layers of the dermis and subcutaneous tissues
  • formation of lesions (damage)
  • remain localized or spreads directly via lymphatic system
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Properties of systemic mycoses:

2 kinds: True and opportunistic systemic mycoses:

True systemic mycoses:
  • inhalation -> pulmonary infection -> dissemination 
  • caused by fungi existing in nature
  • geographic distribution varies
  • no evidence of transmission among humans and animals
  • dimorphism: can have different shapes depending on environmental factors -> can grow in filamentous or yeast form


Opportunistic systemic mycoses
  • any fungus in nature can cause opportunistic mycoses
  • candidiasis causes nosocomial infections (=hospital infections)
  • aspergillosis is the most deadly mold
  • cryptococcosis
  • zygomycosis

What causes higher susceptibility for mycoses?

  • HIV
  • malignancy and chemotherapy
  • organ and bone marrow transplantation
  • Neutropenia, corticosteroid therapy, immunosuppression, graft-versus-host disease (donor cells attack body)

Properties of saprolegnia (cotton wool)

Pathogen of horses and dogs, sometimes in humans
need wet environments to complete its lifecycle, fatal if not treated

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