Prions - TSEs in animals
8 important questions on Prions - TSEs in animals
Properties of chronic wasting disease:
- Disease in wild deer, primarily in western US
- symptoms: drooling, difficulties with swallowing, weight loss
Where does prion stand for?
- resistant to:
- heat
- radiation
- proteolytic enzymes
- nucleases
- conventional desinfectants
- two forms of prions -> normal or abnormal
- PrP-c or PrP-sen -> normal
- PrP-Sc or PrP-res -> abnormal
What are the abnormal prions, and what are their properties?
- 30% a-helix, 43% b-sheets
- cytoplasmic
- amyloid-like character
- Higher grades + faster learning
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What are the normal prions and what are their properties?
- cellular membrane glycoprotein
- expressed on the surface of neuronal cells
- 42% a-helix, 3% b-sheest
- function unknown
What is the difference between encephalitis and prion diseases?
Name 4 detection strategies of TSE:
- MRI
- Classical histology: amyloid plaques and spongeform (-> loss of neurons and vacuolization)
- Immunodetection: western blot detection using anti-prion antibodies
- Prion PCR: PrP-Sc converts PrP-c into aggregated form -> ultrasound breaks down aggregates -> short chains again convert PrP-c into PrP-Sc
What are the physiological functions of PrP?
anti oxidant
involved in transmembrane signal transduction
What happens in Alzheimer's disease, with regard to prions?
No seeding activity observed -> not infectious
The question on the page originate from the summary of the following study material:
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