III.2 Regulation
6 important questions on III.2 Regulation
How does regulation affect Km and Vmax?
Non-competitive inhibition: Vmax decreases
Mixed inhibition: Km increases, Vmax decreases
What are examples of irreversible inhibition?
- Denaturation and/or digestion
- Irreversible binding of agents
- Modifications of primary structure
What is phosphorylation? What is responsible for it?
Protein kinases are responsible for this kind of regulation.
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What is cooperativity? How is it achieved?
What are the T and R state of an enzyme?
What is allostery? What does an allosteric effector?
An allosteric effector affects the equilibrium between the T and R state.
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