II.3 The dynamics of protein structure

7 important questions on II.3 The dynamics of protein structure

What is the proces of protein folding?

Primary structure <--> secondary structure --> motifs --> domains --> tertiairy structure

What is the Anfinsen experiment?

The Anfinsen experiment states that protein structure is programmed by the amino acid sequence.

What is the Levinthal paradoxan?

The Levinthal paradoxan states that if protein folding was entirely random it would take 10^10 years, however in cells it takes only milliseconds.
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Why does the hydrophobic effect take place during protein folding?

The hydrophobic parts turn to the inside when hydrogen bonds are split, this increases the entropy in the surrounding water, which is a preferred state.

What are the levels of energy, entropy and order at the start and end of the folding proces? Is this usual?

At the start of protein folding there is high-energy, high-entropy, and a disorded state. At the end of the folding proces there is low-energy, low-entropy and an ordered state. This is a paradox because usually the entropy increases, here the entropy decreases.

What are the characteristics of soluble proteins?

Soluble proteins are proteins in cytoplasm. The outer part contains hydrophilic amino acids to help the protein solubilize. The hydrophobic amino acids are buried deep inside the protein.

Which state is favored, the folded or unfolded state?

The folded state is favored because it has the lowest inner energy.

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