Alignment by hand - General

3 important questions on Alignment by hand - General

What is the purpose of sequence alignment?

Line up residues that are at the same position in space in ancestral gene/protein

What is the purpose of structural alignment?

Transfer of structural information

What are 4 (kinds of) residues that don't mutate easily?

1. Active site
2. Cysteine in cysteine bridge
3. Glycine with torsion angles
4. N-terminus

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