The Synapse

26 important questions on The Synapse

What year and method proved that the synapse existed?

1933 - electromicroscopy

Most synapses occur between neurons. However, where do the other kind of neurons form? What junction is this called? What does this allow?

Synapses form between neurons and muscles - the neuro-muscular junction.

These cause muscles to contract and allow us to move.

What disease affects the neurons located in the spinal cord? What does this disease do?

ALS (Amyotrophic Lateral Sclerosis) - it gradually restricts movement and eventually leads to death
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Where are neurotransmitters made? How are they transported to the pre-synaptic terminal?

They are made in the cell body. They are then packaged into vesicles and transported along the axon to the presynaptic terminal. They remain dormant until an action potential arrives.

When an action potential arrives along the synapse, what ion channels open?

Calcium (2+) ion channels

What ions cause the release of neurotransmitters into the synapse? How do they do this?

The incoming Ca++ binds to the synaptic vesicles causing them to release their neurotransmitters into the synapse

Ionotropic neurotransmitter receptors are composed of two parts. What are these parts?

One part binds with the neurotransmitter
The other part is an ion channel

Where are inhibitory neurotransmitters released and what kind of receptors do they bind to?

They are released at Type 2 synapses and cause an influx of negative ions (-Cl)

Following their release, what needs to happen to neurotransmitters? What happens when this does not happen?

They need to be removed or inactivated

If this does not happen, prolonged activation can occur which can cause strokes. E.g. not deactivating the neurotransmitter, acetylcholine, means that your muscles are always activated = you cannot control your muslces = paralyses

What neurotransmitter is used at the neuro-muscular junction?

Acetylcholine

What is a side effect of levo-dopa?

Schizophrenic symptoms (especially paranoia)

What do psychoactive drugs do?

They mimic the effect of neurotransmitters by binding directly to neurotransmitter receptors

What are toxins/drugs that block/poison ion channels called?

Antagonist

What are toxins/drugs that mimic neurotransmitters called? Give two examples.

Agonists
E.g. LSD and psilocybe mimic the effect of serotonin

Why do people become addicted to drugs?

They activate the reward system in the brain

What are the four lobes in the cerebral hemispheres? What are their functions?

Occipital lobe: visual processing
Parietal lobe: touch, balance and movement
Temporal lobe: hearing, speech comprehension, memory and visual recognition
Frontal lobe: movement, thinking and planning

What is the Basil Ganglia important for?

The control of voluntary movement

What is the Limbic System important for?

Our navigation in space and memory formation

What does caudal and prosterior mean?

Toward the back

What are the cracks called in the brain's folded surface called?

Sulci

What are spinal nerves part of and what is their function?

They are part of the somatic nervous system. They carry sensory information to the spinal cord from the skin and muscles.They also send motor instructions to control each muscle.

What does the hindbrain control and what is its most distinctive structure?

It controls various motor functions ranging from breathing to balancing to fine movements e.g. dancing.

Cerebellum

What are the components of the midbrain and where are they located?

- The sensory component, the tectum, is located dorsally
- The motor component, the tengmentum is ventral

What difficulties arise when people have deficits in one of the four brain lobes?

Damage to the:
- occipital lobe = deficits in visual processing
- parietal lobe = deficits in identifying or locating stimulation on the skin
- temporal lobe = difficulties in recognising sounds and sometimes processing complex visual information e.g faces
- frontal lobe = difficulties organising behaviour and planning for the future

What are the principle structures of the limbic system?

Hippocampus
Amygdala
Temporal lobe
Limbic cortex 

Where are the olfactory bulbs located?

The front of the brain

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