Het brein in ontwikkeling - Structural Development of the Brain

5 important questions on Het brein in ontwikkeling - Structural Development of the Brain

What is predetermined development?

Genes dictate the structure of the brain, which enables the particular functions of the brain, which determines the kinds of experiences we have.

What is probabilistic development?

Brain structure, and even the expression of genes, can be influences by experience as well as vice versa.

What happens in prenatal development?

The nervous system derives from a set of cells arranged in a hollow cylinder, the neural tube.

The neural tube has organized into a set of bulges and convolutions that will go on to from various parts of the brain.


Closer to the hollow of the neural tube are several proliferative zones in which neurons and glial cells are produced by division of proliferating cells (neuroblasts and glioblasts).
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How does the migration of neurons to the region they have to be occur (two ways)?

1. Passively, older cells tend to be pushed to the surface of the brain. Structures such as the hippocampus are formed this way.

2. Actively, newer cells are guided to particular destinations, pushing past the older cells. Radial glial cells act like Climbing ropes.

What happens during postnatal development?

The expansion in brain volume is due to factors such as growth of synapses, dendrites and axon bundles; the proliferation of glial cells; and the myelination of nerve fibers.

Synaptogenesis: rise and then fall in synapse formation.

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