Cell-cell and cell-matrix adhesions

12 important questions on Cell-cell and cell-matrix adhesions

Which 2 types of junctions do you have?

Occluding, anchoring

Name a type of occluding junctions, and what adapter proteins does it use, and is it connected to the cytoskeleten?

Tight junction, ZO adapter proteins, actin

Name a type of adherins junctions, their adapter proteins and the type of cytoskeleton they use.

Cadherin, Catenins, F-actin (its a sort capping protein)
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Name a type of anchoring junctions, adapter proteins they use and the type of cytoskeleton.

Desmosomes, various proteins, intermediate filaments

What is the function of a gap junction?

Intracellular transport of small molecules through phosphorylation and their form.

Whats the the difference between hemidesmosomes and desmosomes?

Hemidesmosoms are cell-matrix and desmosomes are cell-cell junctions also their structure is different.

Name 2 types of adhesion molecules

CAM, selectin

What do integrins do? And how many do humans contain?

Connect the ECM with actin. 24.

What happens during outside-in signaling?

Integrin gets activated through binding to ECM
1. Integrin binds to ECM
2. Bpart of integrin binds to talin
3. Talin binds to actin

What happens during inside-out signaling?

Integrin gets activated through intracellular signal
1.  activation of talin
2. Binding talin to B-part integrin
3. Change ECM domain integrin
4. Integrin binds to ECM

During inside out signaling talin gets activated, what does this trigger?

Binding of integrins to the ECM, so indirect triggers outside-in activation.

Name a non-protein type of ECM and its function

GAGs, space filling

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