Protein traffic

6 important questions on Protein traffic

The tim and tom receptercomplex can you find in what organel?

Mitochondria, tIm on the Inner membrane, tOm on the Outer membrane

What 3 energy comsumptions find place in the mitochondrial protein import?

-Dissosation of cytosolic Hsc709(ATP)
- Translocation of signal sequence through tim(membrane potential)
- Dissociation of matrix Hsc70(ATP)

What is the largest protein complex in the cell?

The NPC (nuclear pore complex)
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Small proteins can freely diffuse through the NPC why?

Nucleoporins form a network that is a hydrogel which has a permeability barrier.

Which 2 types of karyopherins do exist?

- importins(recognize NLS)
- exportins (recognize NES)

What does the GTPase switch do?

Ran-GEF switches GTP for GDP and turns the switch on
Ran_GAP cleeves of the phosphate group and turns the switch of

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