Case 9; immunology

10 important questions on Case 9; immunology

What can you tell me about the prreventive measure "feed"?

- proper nutrition and general good care of the animals ensure that they are less susceptible to disease
- First instance -> the innate/congenital barriers of the animal are then in a position to withstand intrusion, if this does not work the animal has adequate reserves to build up its immunity rapidly and effectively
- Second instance -> nutrition plays an important role in the occurrence and remedying of metabolic diseases.

What can you tell me about the preventive measure "housing"

- housing systems influence animal welfare, the immune response in general, as well as the risk of infection
- housing system can raise the risk of infection by promoting (in)direct contact between animals, in this way, increasing the risk of the transmission of infectious pathogens

What can you tell me about the preventive measure "cleaning and decontaminating"

- extremely important and effective measures to ensure that the animals come into contact as little as possible with pathogens
- hygiene, decontamination, disinfection
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What can you tell me about the preventive measure "isolation"

- the transmission of pathogens from one animal to another can be reduced by preventing (indirect) contact between animals, or between groups of animals as far as possible

What can you tell me about the preventive measure "vaccination"

- animals are immunised with vaccinations containing inactivated or weakend/attenuated pathogens or respectively parts thereof
-> animal then builds up active immunity very specifically to counter the actual pathogen
- vaccination should occur in the pre-pathogenic phase

What can you tell me about epidemiological research?

- the factors that lead to the transmission of infections are quantified
- the effects of possible prevention and intervention measures are quantified
- initial step is to find factors that may be relevant by means of risk factor research, after which the transmission is modelled and important parameters are estimated for these models from field data and experiments

What can you tell me about the neuro-endocrine regulation? (Aspecific)

- compromises (among other things) the stress response and thermoregulation
- pathogens are also a stress factor, wich generate a stress response as well as an immune response
- adaptation to climate factors occur via two mechanisms: the general stress response and an individual mechanism to maintain body temperature

What can you tell me about phagotosis? (Aspecific)

- the devouring of particles by cells
- certain white blood cells (the neutrophil granulocyte and the macrophages) are able to absorb foreign material and to break them down internally -> occur in blood and lymph, and can move to location of infection
- another function of macrophages -> can present antigens in order to generate a specific immune response

What are the two important forms of the innate/ccongenital immunological system?

1. The phagotosis
2. Enzymes present in blood -> can destroy the infectious particles via a cascade

What can you tell me about specific immune response?

- consist of humoral immunity and cell-mediated immunity
- it depends on the phagocytosis activity of the macrophages, because the alien material processed first has to be offered by the macrophages to the T- and B-lymphocytes before these carry out the immune response

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