RAS-MAPK cascade
3 important questions on RAS-MAPK cascade
What are the 5 steps of the activation of Ras?
1. Receptor binds GRB2
2. GRB2 binds Sos
3. Sos binds Ras
4. GDP dissociates form Ras, GTP binds
5. Active Ras dissociated from Sos
2. GRB2 binds Sos
3. Sos binds Ras
4. GDP dissociates form Ras, GTP binds
5. Active Ras dissociated from Sos
What are the 3 steps of MAPK activation?
1. Ras activates MAPKKK (Raf)
2. Raf activates MAPKK (MEK)
3. MEK activates MAPK
2. Raf activates MAPKK (MEK)
3. MEK activates MAPK
What are the two possible effects of Ras-MAPK cascade?
1. Changes in protein activity
2. Changes in gene expression
2. Changes in gene expression
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