(direct) posttranslational transport - mitochondrial proteins

3 important questions on (direct) posttranslational transport - mitochondrial proteins

Where is the targeting sequence located in proteins that go to the mitochondria?

N-terminus

What are the 4 steps to transport a protein into the mitochondrial matrix?

1. Protein finds receptor associated with protein translocator
2. Translocator lines up with a second protein translocator
3. Protein is translocatied into mitochondrial matrix
4. Targeting sequence is cleaved of

What are chaperon proteins?

Proteins that prevent misfolding and help guide the protein through the translocator

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