Fission and fusion

4 important questions on Fission and fusion

Which proteins are involved in fusion?

OPA1, Mfn1, Mfn2

How can OPA1 processing trigger apoptosis?

L-OPA1 normally blocks the cristea, the TM is cut of by OMA1, this opens the cristea and can lead to apoptosis

Which proteins are involved in fission?

Drp1 and adaptor proteins
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What are the 3 steps of mitochondrial fission?

1. Drp1 is recruited by adaptor protein
2. Drp1 forms ring around mitochondrion
3. Mitochondria are pinched off

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