Secretory pathway transport - targeting to the ER
3 important questions on Secretory pathway transport - targeting to the ER
Where is the signal seqeunce located in proteins that go to the ER?
N-terminus
What are the 8 steps to get the protein into the ER?
1. Protein comes out of ribosome
2. SRP binds ribosome
3. SRP binds receptor on ER
4. Ribosome docks translocon
5. Translocon opens
6. Peptide chain moves through translocon while being made
7. Signal sequence is cleaved
8. Ribosome detaches from ER
2. SRP binds ribosome
3. SRP binds receptor on ER
4. Ribosome docks translocon
5. Translocon opens
6. Peptide chain moves through translocon while being made
7. Signal sequence is cleaved
8. Ribosome detaches from ER
What is the function of a stop transfer anchor sequence?
It lets the translocon opens sideways and pushes the protein out to the side. It is used for transmembrane proteins
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