Hunger, Eating and Health - Human Obesity: Causes, Mechanisms, and Treatments - Leptin and the Regulation of Body Fat
5 important questions on Hunger, Eating and Health - Human Obesity: Causes, Mechanisms, and Treatments - Leptin and the Regulation of Body Fat
What is an ob/ob mouse?
A mouse that has both the ob/ob alleles and is therefore leptin deficient. It was discovered by accident and the mouse who were leptin deficient were obese!
Which findings reported that insulin serves as a negative feedback signal for the regulation of body fat?
1. Brain levels of insulin were positively correlated with levels of body fat.
2. Insulin receptors were found in the brain.
3. Infusions of insulin into the brains reduced eating and body weight in rats.
Where are receptors for both peptides (leptin and insulin) mainly located?
Arcuate Nucleus
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There are two classes of neurons in the arcuate nucleus. What classes are they?
1. Neuropeptide Y
2. Melanocortin releasing neurons. Melanocortins is a class of peptides that includes aMSH.
Why does leptin not work as a treatment for obesity?
People with obesity have rather high rates of leptin.
It only works if someone is leptin deficient.
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