Eating disorders and the brain

12 important questions on Eating disorders and the brain

What are markers of glucose sensing cells?

Katp-channels
GLUT2
Glucokinase

What happens if you make lesions in the ventromedial nucleus?

Appetite grows

What happens in you make lesions in the extreme lateral part of the hypothalamus?

Loss op appetite
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What are some factors which influence feeding?

Internal motivation
Circadian rhythm
Individual experience
Specific nature of food

What is the homeostasis in feeding?

Eat when hungry, stop when satiated

What part of the brain is responsible for feeding homeostasis?

Hypothalamus

What are peptides that inhibit feeding?

POMC and CART

What are peptides that stimulate feeding>

NPY
Agrp

When do the extracellular dopamine levels increase in nucleus accumbens?

With substances that are rewarding

What is the role of dopamine in regard to food?

It is thought to be more involved in anticipatory/approach phase of feeding.

Which substance is responsible for the liking of food?

Opioids

What happens when you block opioid receptors?

Decreases food intake and in humans it is reported it reduces the pleasantness of food

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