Molecular Information Flow and Protein Processing - Bidirectional Replication, the Replisome, and Proofreading
9 important questions on Molecular Information Flow and Protein Processing - Bidirectional Replication, the Replisome, and Proofreading
Replicating molecules of characteristic shapes
Large replication complex that binds and initiates synthesis
Subcomplex formed by helicase and primase that facilitates the sequential activities of the two enzymes during the replication process
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The work of the of replisome is finished when the replication forks collide at the opposite side of the chromosome from the origin called
In the teminus region are several DNA sequences called _______ sites that are recognized by a protein called Tus.
Functions to block progress of the replication forks
Facilitates DNA partitioning, a protein that orchestrates several key events in the cell division process
DNA polymerases effectively get two chances to incorporate the correct base at any given site. The first chance comes when DNA Pol III inserts bases according to the base-pairing rules (Figure 4.1c). The second chance comes when a Process called ____________ takes place
During replication, if an incorrect base has been inserted, a mismatch in base pairing occurs. Both _______ and ________ possess a 3′ -----> 5′ exonuclease activity that can remove such mismatched nucleotides. The polymerase detects the error because Incorrect base pairing causes a slight distortion in the topology of the double helix.
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