Metabolic regulation - other global control networks

3 important questions on Metabolic regulation - other global control networks

Some proteins are less stable at elevated temperatures ad tent to unfold. What is an other wordt for unfolding?

Denature

What two 'omega' factors controle the heat shock response?

  • RpoH
  • RpoE

Steps in the heat shock respone when temp is high

  • Proteins denaturate
  • DnaK recognizes, binds and refolds these unfolded polypeptide chains.
  • this removes RpoH from DnaK, which slows the degradation rate.
  • when the level of RopH rises, the heat shock genes are transcribed

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