L2 tumour suppressor genes

4 important questions on L2 tumour suppressor genes

When Ras is mutated, what function does it lose?

GTPase function (therefore protein always active)

3 types of Tumour suppressor gene protein functions

regulate cell cycle entry (p16 or Rb)
receptors or signal transducers for inhibiting molecules of cell cycle
checkpoint proteins that can arrest cell cycle

Transcription factors which make cell proliferation vs quiescence decision of Rb

E2F (1, 2 and 3)
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Consequences of loss of checkpoint controls

loss of chromosomes

fragile sites (not stopping to repair stalled replication forks

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