L2 tumour suppressor genes
4 important questions on L2 tumour suppressor genes
When Ras is mutated, what function does it lose?
3 types of Tumour suppressor gene protein functions
receptors or signal transducers for inhibiting molecules of cell cycle
checkpoint proteins that can arrest cell cycle
Transcription factors which make cell proliferation vs quiescence decision of Rb
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Consequences of loss of checkpoint controls
fragile sites (not stopping to repair stalled replication forks
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