L2 oncogenes

4 important questions on L2 oncogenes

3 critical genes for cancer (what they do)

1. Oncogenes (growth signalling)
2. Tumour suppressor genes (inhibit growth)
3. caretaker genes (repair DNA)

Receptor class which growth factors signal through?

Tyrosine kinase (RTKs)

What does the binding of the growth factor do to the tyrosine kinase receptor

stabilises the dimer to activate the kinase domain by transphosphorylation
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What do oncogenic GF Receptors do

promote proliferation in absence of external GFs

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