How does a fatty liver develop?

9 important questions on How does a fatty liver develop?

What is the difference between fibrosis and cirrhosis?

Fibrosis is still reversible, cirrhoris is irreversible.

What factors influence fatty liver?

Factors that influence fatty liver are:
  • obesity
  • insulin resistance
  • (MetS)
  • genetic factors
  • environmental factors
  • high-fat, high calorie diet

What are the risk factors for fatty liver?

Risk factors for fatty liver:
  • older age
  • BMI
  • insulin resistance
  • diabetes
  • MetS
  • histological NASH
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What is role in insulin in fatty liver development?

less insulin --> lipolysis is less inhibited --> more fatty acids go to the liver via circulation

When does the liver take up more fatty acids?

The liver takes up more fatty acids when fat oxidation is too low or synthesis is too high.

What are the stage of fatty liver?

steatosis --> steatohepatitis/NASH --> fibrosis --> cirrhosis

What is going on in the fibrosis stage?

Fibrosis = activation of stellate cells which produce collagen (which leads to cirrhosis) 

What are stellate cells?

Stellate cells play a role in reparing liver damage. 
They take up oxidized LDL

Which genes are associated with fatty liver?

adiponutrin gene --> phospholipase domain containing protein 3 is associated with fatty liver. 

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