What are myokines and what is their role in metabolic syndrome? (MLW/BW)

7 important questions on What are myokines and what is their role in metabolic syndrome? (MLW/BW)

What is role of insulin resistance in myokine production?

The degree of insulin resistance of the muscle determines which myokines are produced.

What happens to IL-6 during exercise?

exercise --> increase up to 100-fold of IL-6

Which anti-inflammatory myokines are produced in acute exercise?

IL-1 and IL-10
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Which myokine is present in chronic disease/MetS?

NfkB (pro-inflammatory)

What is the effect of TNFalpha on insulin resistance?

TNFalpha --> activation of kinases --> IRS-2 tyrosine phosphorylation decreases --> insulin resistance

What is the role of myostatin in muscle hypertrophy?

Myostatin --> acts on Akt in IGF-1/Akt/mTor pathway --> inhibits muscle hypertrophy

What is the influence of exercise on myostatin?

During strenght exercise myostatin is downregulated.

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