Summary: Case 5
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Read the summary and the most important questions on Case 5
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1 Thymus
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What is the function of the Thymus?
Maturation of T- Lymphozytes -
What is the location of the Thymus?
Superior anteriormediastinum, retrosternal, precordial -
What is the basic histology of the Thymus?
Cortex with densely packed immature T-cells
Medulla with mature T-cells -
2 T-cells
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2.1 Development
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What do the thymic cortical cells express for positive selection?
MHC class I & MHC class II receptors -
What does positive selection do?
If T-cell receptors can bind appropriately to MHC (not too strong & not too weak) -
What do dysfunctional cells do after positive selection?
Apoptosis -
What is the location of negative selection of T cells?
Thymic medulla -
What cells pass negative selection?
T cells that di not bind to the antigens presented -
What is self antigen presentations regulated by?
AIRE (autoimmune regulator) protein -
2.3 T- cell activation
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How are antigens processed?
By dendritic cells via phagocytosis and then presentation to lymph node via MHC I or II
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