How can the pro- and anti-inflammatory mediators of macrophages influence the lipid intermediates and vice versa?

4 important questions on How can the pro- and anti-inflammatory mediators of macrophages influence the lipid intermediates and vice versa?

How do Gram negative bacteria influence gut colonization?

Gram negative bacteria --> influences TLR --> increase in TNF-alpha --> more firmicutes

How does PPAR influence inflammation?

FAs are ligands for PPAR --> PPAR-delphi and PPAR-gamma induced by th2-cytokines--> more inflammation
PPAR works with LXR --> inhibits inflammation

What happens to PPAR in obesity?

obesity --> more saturated FA --> less PPAR --> less inhibition of inflammation
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What is the role of adiponectin in inflammation?

Adiponectin --> activates AMPK and sirt1 --> inhibits NFkB --> inhibits M1 --> more inflammation

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