What adipokines are secreted in the MetS? Which are increased, which are decreased? - Adiponectin

4 important questions on What adipokines are secreted in the MetS? Which are increased, which are decreased? - Adiponectin

When do adiponectin levels decrease?

The secretionlevel of adiponectin is inversely proportional to BMI. So the adiponectin levels decrease when BMI increases.

When do adiponectin levels increase?

Adiponectin levels increases in chronic inflammatory and autoimmune diseases, e.g. type 1 diabetes mellitus.

Which are the receptors for adiponectin and where are they expressed?

The receptors for adiponectin are the adiponectin receptor proteins 1 and 2. They are expressed in cardiac tissue.
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Is adiponectin anti- or proatherogenic and why?

Adiponectin has antiatherogenic properties, because it modulates the endothelial inflammatory response by inhibiting both expression of endothelial cell-selective adhesion molecules and monocyte adhesion to the vascular endothelium.

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