What adipokines are secreted in the MetS? Which are increased, which are decreased? - Apelin

3 important questions on What adipokines are secreted in the MetS? Which are increased, which are decreased? - Apelin

When do apelin levels increase?

Apelin levels increase with obesity.

What is the response to apelin?

Apelin enhances a protective response. Effects are:
  • endothelium-dependent vasodilatation
  • lowers blood pressure (in rats, via pathways...)

What are the effects of treatment with apelin?

The effects of treatment with apelin are:
  • diminishing of the formation of aortic aneurysms
  • reduce macrophage infiltration
  • lower the production of proinflammatory cytokines and chemokines

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