What adipokines are secreted in the MetS? Which are increased, which are decreased? - Leptin

5 important questions on What adipokines are secreted in the MetS? Which are increased, which are decreased? - Leptin

When do the leptin levels increase?

Leptin levels are proportional to the total adipose tissue mass. So when the adipose tissue mass increases (weight gain e.g. in metabolic syndrome), the leptin levels increase.

On what receptor does leptin act?

Leptin acts on the leptin receptor. It is expressed in many tissues.

What is the function of leptin?

Leptin modulates food intake by suppressing agouti-related protein and neuropeptide Y and upregulating coritcoliberin and melanotropin-alpha. 
It downregulates food intake.
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What is the role of leptin in lipotoxicity?

Leptin reduces lipotoxicity, by fatty-acid-induced apoptosis.

What are the atherogenic effects of leptin?

Atherogenic effects of leptin:
  • induction of endothelial dysfunction
  • stimulation of inflammation
  • generation of oxidative stress
  • reduction of serum paraoxonase/arylesterase activity
  • enhancement of platelet aggregation
  • migration, hypertrophy and proliferation of vascular smooth muscle cells

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