What is the relationship between adipose tissue oxygen tension and inflammation?
3 important questions on What is the relationship between adipose tissue oxygen tension and inflammation?
How is oxidative stress reflected in the adipose tissue of obese humans?
Oxidative stress in adipose tissue of obese humans is reflected by:
- lipid peroxidation
- protein carbonylation
- DNA damage
Particularly in people with obesity and insulin resistance.
What happens to oxidative stress when lipolysis is stimulated?
Oxidative stress increases when lipolysis in the adipocytes is stimulated.
Energy demand of fatty acid re-esterification --> increase in AMP/ATP ratio --> activation of AMPK
AMPK activation prevented --> ROS release increases --> AMPK activity decreases --> cause of result of oxidative stress in adipocyte
What precedes insulin resistance in most obese individuals?
An increase in leukocyte infiltration and inflammatory cytokines precede insulin resistance in obese individuals.
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