Omeprazole

4 important questions on Omeprazole

Why is Omeprazole/Esomeprazole given as an enteric coated drug?

Omeprazole/Esomeprazole needs the enteric coat to prevent degradation in the stomach, since it has to be absorbed into the systemic circulation to function.

Why are NSAIDs recommended in combination with Omeprazole/Esomeprazole?

Since Omeprazole/Esomeprazole inhibits acid secretion in the stomach, gastric damage from NSAIDs, that inactivate gastric protective molecules, is prevented.

What are negative consequences of the higher gastric pH due to proton pump inhibition by Omeprazole/Esomeprazole?

Negative consequences are:
  • passing of bacteria
  • reduced break down of proteins by pepsin
  • reduced release of vitamin B12 from food 
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Why should Omeprazole/Esomeprazole not be taken in combination with grapefruit?

Since Omeprazole/Esomeprazole is metabolized in the liver by the CYP-450 system, grapefruit inhibits the metabolisation, thereby causing accumulation of Omeprazole/Esomeprazole.

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