Ipratropium

4 important questions on Ipratropium

What is the working mechanism of Ipratropium?

Ipratropium inhibits the parasympathetic nervous system: it has an antagonistic effect on the muscarinic receptors in the lungs, thereby causing bronchodilation.

What is the working mechanism of Salbutamol?

Salbutamol stimulates the sympathetic nervous system: it has an agonistic effect on the beta-2-receptors in the lungs, thereby causing bronchodilation.

Why should Ipratropium rather not be given to patients with benign prostatic hyperplasia?

Since Ipratropium inhibits the parasympathetic nervous system, it may decrease contractility of the bladder, thereby causing complicated urination.
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To which local effects in the GI tract may swallowing of Ipratropium lead?

Since Ipratropium inhibits the parasympathetic nervous system, it may cause dry mouth, throat irritation, motility disorders and inhibited mucus secretion in the GI tract.

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