Oxazepam
3 important questions on Oxazepam
Why should patients with impaired hepatic function be treated with Oxazepam instead of Diazepam?
Since Oxazepam is an active metabolite of Diazepam from the liver, the risk of overdosing due to impaired biotransformation by the liver is prevented.
What is the effect of the binding of GABA-molecules to the GABA A receptor if Oxazepam is also bound?
If both GABA and Oxazepam are bound to the GABA A receptor, the chlorine canal remains open longer, which results in increased chlorine passing the canal, that causes pronounced depolarization, thereby inhibiting the new action potential.
What is the effect of Oxazepam in combination with alcohol?
Since Oxazepam and alchol both act on the central nervous system, their individual effects are additive to each other.
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